姓名：吉敬 

 性别：女

 职称：副教授

 职务：硕士生导师

 学历学位：博士研究生

本人简介：

中国药科大学博士、英国威廉希尔体育公司硕士生导师、威廉希尔体育实验中心主任、江苏省海洋药物活性分子筛选重点实验室常务副主任、江苏省“青蓝工程”优秀骨干教师、江苏省科技副总、江苏省药理学会理事、连云港市“521工程”第三层次培养对象。长期从事神经退行性疾病的发病机制、蛋白质的翻译后修饰及其在疾病中的作用研究。近 3 年在Cell Death Dis (Nature子刊)、Cell Death Differ (Nature子刊)、 、Phytomedicine等杂志上发表学术论文共30余篇，主持国家自然科学基金1项、江苏省高校面上项目 1 项和江苏省“青蓝工程”优秀骨干教师项目1项，参与国家自然科学基金 、省杰出青年基金项目等多项。

学习和工作经历：

（1）教育经历（从大学本科开始）

2008.09-2012.06   中国药科大学 中药资源与开发 本科

2012.09-2017.06   中国药科大学 药理学 博士（硕博连读）

（2）研究工作经历

2017.09- 至今 英国威廉希尔体育公司 威廉希尔体育教师

2017.12-2019.12  江苏省 科技副总

2018.08-2019.07  江苏省科技镇长团 灌南县组织部人才办副主任

2019.08-2020.07  江苏省科技镇长团 灌南县新集镇副镇长

2020.06- 至今 英国威廉希尔体育公司 威廉希尔体育实验中心主任/药物制剂系支部书记

      2021.10-  至今 江苏省海洋药物活性分子筛选重点实验室 常务副主任

主要研究项目：

1. Keap1/Nrf2调控小胶质细胞焦亡在阿尔茨海默症中的作用及机制研究，国家自然科学基金项目（82104174），主持

2. 靶向 Keap1 调节 Keap1/Nrf2 复合体稳态在 AD 中的作用及机制研究，江苏省高等学校自然科学研究 面上项目( 20KJB350008)，主持

3. 银杏二萜内酯葡胺注射液抗脑缺血损伤配伍优效性及其机制研究，国家重点实验室标志性成果培育项目（SKLNMBZ201405），主持

4. 通道式222nm准分子紫外消杀设备（HJ606）的开发，横向课题（JOUH22303），主持

5. 新型抗肿瘤新药HDAC11项目药物分子的设计、合成及临床前药效学评价研究，横向课题（JOUH22582），主持

6. 新型抗肿瘤新药COPS5项目药物分子的设计、合成及临床前药效学评价研究，横向课题（JOUH22590），主持

7. 1β, 3β, 23-三羟基齐墩果烷-12-烯-28-酸治疗尿酸性肾病的分子机制研究，国家自然科学基金项目（81202573），主要参与

8. 5.R-9-(4氟苯基)-3-甲基-10,10,-二氢-6氢-苯并吡喃抗阿尔茨海默病的作用机制研究，国家自然科学基金项目（81603113），主要参与

代表性成果：

【获得省级及以上奖励】

2019年  江苏省科技镇长团优秀团员 省级奖励

2022年 江苏高等教育学会 高校实验室管理先进个人 省级奖励

2022年“领航杯”江苏省教师信息素养提升实践活动 高等教育组 省级二等奖

2021年江苏省教学成果奖“四平台五联合协同培养医药产业应用型人才的研究与实践” 省级二等奖

【期刊论文】

1. Ji J, Shen J, Xu Y, Xie M, Qian Q, Qiu T, Shi W, Ren D, Ma J, Liu W, Liu B. FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. Cell Death Dis. 2022 May 7;13(5):442. doi: 10.1038/s41419-022-04892-9. PMID: 35525855; PMCID: PMC9079088.

2. Ji J, Xu Y, Xie M, He X, Ren D, Qiu T, Liu W, Chen Z, Shi W, Zhang Z, Wang X, Wang W, Ma J, Qian Q, Jing A, Ma X, Qin J, Ding Y, Geng T, Yang J, Sun Z, Liu W, Liu S, Liu B. VHL-HIF-2α axis-induced SEMA6A upregulation stabilized β-catenin to drive clear cell renal cell carcinoma progression. Cell Death Dis. 2023 Feb 4;14(2):83. doi: 10.1038/s41419-023-05588-4. PMID: 36739418; PMCID: PMC9899268.

3. Hu Y, Xie J, Chen L, Tang Q, Wei W, Lin W, Du W, Xiang T, Yin L, Ji J*. Integrated Analysis of Genomic and Transcriptomic Profiles Identified the Role of GTP Binding Protein-4 (GTPBP4) in Breast Cancer. Front Pharmacol. 2022 Jun 16;13:880445. doi: 10.3389/fphar.2022.880445. PMID: 35784753; PMCID: PMC9243593.

4. Ji J, Zhang Z, He X, Pan G, Li G, Lv J, Xu Y, Xie M, Feng J, Wang W, Liu B, Ma J, Wang X. A novel ribociclib derivative WXJ-103 exerts anti-breast cancer effect through CDK4/6. Anticancer Drugs. 2022 Dec 19. doi: 10.1097/CAD.0000000000001475. Epub ahead of print. PMID: 36729405.

5. Ji J, Liu W, Xu Y, Xu Z, Lv M, Feng J, Lv J, He X, Zhang Z, Xie M, Jing A, Wang X, Ma J, Liu B. WXJ-202, a novel Ribociclib derivative, exerts antitumor effects against breast cancer through CDK4/6. Front Pharmacol. 2023 Jan 19;13:1072194. doi: 10.3389/fphar.2022.1072194. PMID: 36744210; PMCID: PMC9894725.

6. Shen J, Xie M, Xu Y, Qian Q, Qiu T, Shi W, Ren D, Ji J*, Huang J*. Identification of the deubiquitinase USP28 as a novel molecular therapeutic target of ovarian cancer. Biochem Biophys Res Commun. 2023 Jan 1;638:184-191. doi: 10.1016/j.bbrc.2022.11.055. Epub 2022 Nov 21. PMID: 36462492.

7. Ji J, Xie M, Qian Q, Xu Y, Shi W, Chen Z, Ren D, Liu W, He X, Lv M, Ma J, Liu W, Li A, Liu B*. SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. Biochem Biophys Res Commun. 2022 Jan 8;587:139-145. doi: 10.1016/j.bbrc.2021.11.099. Epub 2021 Nov 30. PMID: 34872002.

8. Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B, Tan M. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ. 2022 Jan;29(1):1-13. doi: 10.1038/s41418-021-00827-7. Epub 2021 Jul 2. PMID: 34215846.

9. Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J*, Hu Q*. The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis. Phytomedicine. 2021 Jul;87:153571. doi: 10.1016/j.phymed.2021.153571. Epub 2021 Apr 20. PMID: 33994056.

10. Yu H, Yang X, Zhang J, Yang H, Zhao P, Shen H, Jiang GE, Ji J*, Dong J*, Gao S*. A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp. Acta Biochim Biophys Sin (Shanghai). 2021 Mar 2;53(3):381-384. doi: 10.1093/abbs/gmaa175. PMID: 33404640.

11. Wan J, Liu S, Sun W, Yu H, Tang W, Liu W, Ji J*, Liu B*. Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. Cancer Cell Int. 2021 Feb 18;21(1):122. doi: 10.1186/s12935-021-01806-1. PMID: 33602225; PMCID: PMC7890835.

12. Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Ji J, Liu W, Liu B. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. Cell Death Dis. 2021 Jul 31;12(8):758. doi: 10.1038/s41419-021-04040-9. PMID: 34333526; PMCID: PMC8325689.

13. Jin M, Duan J, Liu W, Ji J, Liu B*, Zhang M*. Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells. Cancer Cell Int. 2021 Apr 1;21(1):191. doi: 10.1186/s12935-021-01897-w. PMID: 33794893; PMCID: PMC8017762.

14. Liu B#, Xiang L#, Ji J, Liu W, Chen Y, Xia M, Liu Y, Liu W, Zhu P, Jin Y, Han Y, Lu J, Li X, Zheng M, Lu Y*. Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2. J Clin Invest. 2021 Oct 15;131(20):e144801. doi: 10.1172/JCI144801. PMID: 34651580; PMCID: PMC8516465.

15. Shen J, Zhu Y, Zhou B, Kong L, Jin Y, Zhang D, Cao Z, Ji J, Li J*. In vitro and in vivo evaluation of a water-in-oil microemulsion of platycodin D. Arch Pharm (Weinheim). 2021 Aug;354(8):e2000497. doi: 10.1002/ardp.202000497. Epub 2021 Apr 12. PMID: 33844326.

16. Wang J, Tang W, Chen S, Zhang J, Ji J, Dong J, Liu G, Gao S. Rapid and sensitive detection of Vibrio alginolyticus pathogenic strains by real-time recombinase polymerase amplification. Acta Biochim Biophys Sin (Shanghai). 2021 Jul 5;53(7):950-954. doi: 10.1093/abbs/gmab051. PMID: 33871545.

17. Yang X#, Ji J#, Liu C, Zhou M, Li H, Ye S, Hu Q*. HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2. Int Immunopharmacol. 2020 Jun;83:106383. doi: 10.1016/j.intimp.2020.106383. Epub 2020 Mar 16. PMID: 32193099.

18. Tong HJ, Shi Y, Ji J, Gao X, Yang DY, DU SL, Li WD, Qin KM*. [Network pharmacology study on potential active components in volatile oil of Dictamni Cortex]. Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(5):1135-1141. Chinese. doi: 10.19540/j.cnki.cjcmm.20191205.201. PMID: 32237457.

19. Li J#, Ji J#, Xu R, Li Z*. Indole compounds with N-ethyl morpholine moieties as CB2 receptor agonists for anti-inflammatory management of pain: synthesis and biological evaluation. Medchemcomm. 2019 Sep 17;10(11):1935-1947. doi: 10.1039/c9md00173e. PMID: 32952995; PMCID: PMC7478157.

20. Shi Y , Zhan Y , Shi D , Ji J, et al. Quantitative and chemical fingerprint analysis for the quality evaluation of fructus arctii by HPLC coupled with hierarchical clustering analysis[J]. LATIN AMERICAN JOURNAL OF PHARMACY, 2019, 38(4):643-650.

21. Jian Y#, Ji J#, Huang Z#, et al. Enantiomers of 3-pentylbenzo [c] thiophen-1 (3 H)-one: preparation and evaluation of anti-ischemic stroke activities[J]. RSC advances, 2016, 6(43): 36888-36897.

22. Yin W#, Lan L#, Huang Z#, Ji J, Fang J, Wang X, Ji H, Peng S, Xu J, Zhang Y*. Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent. Eur J Med Chem. 2016 Jun 10;115:369-80. doi: 10.1016/j.ejmech.2016.03.044. Epub 2016 Mar 19. PMID: 27031213.

23. Chen T., Gao J, Xiang P, Chen Y, Ji J, et al. Treatment with Akebia Saponin D Ameliorates Aβ1–42-Induced Memory Impairment and Neurotoxicity in Rats[J]. Molecules, 2016, 21(3):323.

24. Chen T, Gao J, Xiang P, Chen Y, Ji J, Xie P, Wu H, Xiao W, Wei Y, Wang S, Lan L, Ji H, Yan T*. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. Int Immunopharmacol. 2015 Jun;26(2):338-48. doi: 10.1016/j.intimp.2015.04.001. Epub 2015 Apr 15. PMID: 25887267.

25. Bo W, Wen Li, Ji J, Hui ji*. The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats[J]. Atherosclerosis, 2014, 235(2): 318-327.

26. Hu QH, Zhu JX, Ji J, Wei LL, Miao MX, Ji H*. Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules. 2013 Jul 29;18(8):8976-93. doi: 10.3390/molecules18088976. PMID: 23899832; PMCID: PMC6269767.

联系方式：

电子邮箱: jijing@jou.edu.cn