姓名:马少杰
性别:男
职称:校聘副教授
职务:硕士生导师
学历学位:博士研究生
本人简介:
2012年7月毕业于皖南医学院药学专业,获理学学士学位
2015年7月毕业于广东威廉希尔体育药物化学专业,获医学硕士学位
2015年9月至2018年6月南京医科大学康达学院教师/助教
2022年9月毕业于华中科技老员工命科学与技术学院生物物理学专业,获理学博士学位
2022年至今威廉希尔体育
马少杰,中共党员,博士研究生,威廉希尔体育校聘副教授、硕士生导师。目前主要从事生物大分子计算机模拟和计算机辅助药物分子设计研究。主持英国威廉希尔体育公司人才引进科研基金项目1项,在研项目经费15万元。在《JACS》、《Science Advances》、《PNAS》等国内外期刊上发表20余篇SCI学术论文,其中第一作者及通讯作者9篇。
主要研究方向介绍:
(1)针对重大疾病的药物先导化合物发现和优化;
(2)靶标-配体识别作用机制研究;
(3)蛋白质结构功能的分子动力学模拟研究。
主要研究项目:
三萜类化合物对水通道蛋白1调控的分子动力学模拟及活性优化研究,英国威廉希尔体育公司人才引进科研基金项目,2022-2025年,项目负责人
代表性成果:
1. Qian, J.; Zou, J.; Liu, S.; Zhang, X.; Li, R.; Zhang, Z.; Liu, W.; Ma, S.*; Shi, D*. Synthesis, Characterization, Crystal Structure, and cholinesterase Inhibitory Activity of 2-Phenylthiazole Derivatives. Journal of Molecular Structure 2023, 135248. (IF: 3.841, 共同通讯);
2. Zou, J.; Qian, J.; Liu, S..; Li, R.; Zhang, X.; Yang, S.; Liu, Y.; Liu, W.; Ma, S.*; Shi, D*. Design, Synthesis, Biological Evaluation and Molecular Dynamics Simulations Study of Genistein-O-1,3,5-Triazine Derivatives as Multifunctional Anti-Alzheimer Agents. ChemistrySelect 2022, 7, e202203997. (IF: 2.307, 共同通讯);
3. Xie, H.#; Ma, S.#; Zhao, Y.; Zhou, H.; Tong, Q.; Chen, Y.; Zhang, Z.; Yu, K.; Lin, Q.; Kai, L.; Liu, M.; Yang, J. Molecular Mechanisms of Mercury-Sensitive Aquaporins. Journal of the American Chemical Society 2022, 144, 22229-22241. (IF: 16.383);
4. Xia, J.; Ma, S.; Zhu, X.; Chen, C.; Zhang, R.; Cao, Z.; Chen, X.; Zhang, L.; Zhu, Y.; Zhang, S. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science advances 2022, 8, eabj1262. (IF: 14.957);
5. Gao, R.#; Tan, H.#; Li, S.#; Ma, S.; Tang, Y.; Zhang, K.; Zhang, Z.; Fan, Q.; Yang, J.; Zhang, X.-E.; Li, F. A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability. Proceedings of the National Academy of Sciences 2022, 119, e2104964119. (IF: 12.779);
6. Ma, S.; Zhang, Y.; Zhang, X.; Xie, H.; Tong, Q.; Yu, K.; Yang, J. Dynamic Interactions Between Brilliant Green and MscL Investigated by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations. Chemistry – A European Journal 2022, 29(3), e202202106. (IF: 5.02);
7. Ma, S.; Xie, H.; Yu, K.; Yang, J. Mechanism of unusual AQP6 activation by mercury binding to a pore-external residue C155. Biochemical and Biophysical Research Communications 2022, 618, 1-7. (IF: 3.322);
8. Ma, S.; Li, H.; Yang, J.; Yu, K. Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein. Biochimie 2021, 187, 1-13. (IF: 4.372);
9. Ma, S.; Zhou, S.; Lin, W.; Zhang, R.; Wu, W.; Zheng, K. Study of novel pyrazolo[3,4-d]pyrimidine derivatives as selective TgCDPK1 inhibitors: molecular docking, structure-based 3D-QSAR and molecular dynamics simulation. RSC Advances 2016, 6, 100772-100782. (IF: 4.036);
10. Ma, S.; Tan, S.; Fang, D.; Zhang, R.; Zhou, S.; Wu, W.; Zheng, K. Probing the binding mechanism of novel dual NF-κB/AP-1 inhibitors by 3D-QSAR, docking and molecular dynamics simulations. RSC Advances 2015, 5, 81523-81532. (IF: 4.036);
11. Ma, S.; Zeng, G.; Fang, D.; Wang, J.; Wu, W.; Xie, W.; Tan, S.; Zheng, K. Studies of N9-arenthenyl purines as novel DFG-in and DFG-out dual Src/Abl inhibitors using 3D-QSAR, docking and molecular dynamics simulations. Molecular BioSystems 2015, 11, 394-406. (IF: 3.336);
联系方式:
电子邮箱:msjgdpu@126.com
(2023年2月更新)